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Sunday, December 1, 2013

DEFINITION

bio DEFINITION Osteogenisis imperfecta (OI) is a rargon genetic disorder of collagen deduction associated with broad(a) spectrum of musculoskeletal problems, al intimately notably bowing and fractures of the extremities, muscle builder weakness, ligamentous laxity, and spinal deformities. (Binder, 386). Other collagen-containing extraskeletal tissues, such as the sclerae, the teeth, and the heart valves be also affected to a variable degree. OI has a coarse feature of bony fragility associated with defective formation of collagen by osteoblasts and fibroblasts.
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(Smith, 1983, 13) This disease, involving defective development of the connective tissues, is usually the root of the autosomal dominant gene, but can also be the matter of the autosomal recessive gene. Spontaneous mutations are common and the clinical presentation of the disease remains to be quite broad. (Binder, 386) OI is most commonly referred to as brittle bones, but another(prenominal) names include: fragilitas ossium, hyp...If you want to get a replete(p) essay, order it on our website: OrderCustomPaper.com

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